Effect of Small-Dose Sufentanil Targer-Controlled Infusion Combined with Propofol

 

 

 

 

Dong Hee Kim, M.D.

 

Dept. of Anesthesiology, College of Medicine,

Dankook University, Cheon An, Korea

 

 

Background: Hypnotics and opioids interact synergistically to block responses to surgery and different dose combinations may be used to provide adequate analgesia. We studied the optimal concentration of propofol combined with small-dose sufentanil and reduction of propofol consumption by sufentanil. In this study, our aim was to assess the clinical use of propofol-sufentanil total intravenous anesthesia (TIVA) for plastic and urological surgery and to quantify the influence of the small-dose sufentanil on propofol requirements, stability of anesthesia, and recovery.

 

Methods: TCI of propofol was administered to 60 patients undergoing plastic and urological surgery. In sufentanil group(n=30), TCI of sufentanil (Tc=0.05 mg/mL) was combined to propofol. The propofol target concentration was adjusted to keep mean blood pressure within 30% of reference value and bispectral index between 40 and 60.

 

Results: Propofol target concentration decreased significantly with sufentanil TCI (5.1 vs 3.0 μg/mL) as well as propofol consumption (740 vs 474 mg/h) compared with control group (p<0.05). The range of plasma propofol concentrations was 2 - 6.6 μg/ml. There were no significant differences in side effects between the groups. Induction and recovery time was significantly delayed in control group compared with sufentanil group(p<0.05).

 

Conclusions: TIVA with propofol and sufentanil TCI mode combination is suitable for general anesthesia for plastic and urological surgery.